Effects of lead exposure on thymic output naive t cells function 慢性鉛接觸者胸腺輸出近期功能的研究
Depending on their level of mauriy , dcs express proininnt 1evels of mhc class l and class ii molecules , as well as costdrilatory molecules such as cd40 , cd80 , and cd86 . wl studies show them to be responsible pranarily for sensitto naive t cells in their first empsure to anigen 但是,近年來的研究表明, dc是一類異質性細胞群體,具有不同的亞群和不同的功能狀態(tài),不但在增強免疫反應上具有特別重要的作用,也具有誘導特異性的免疫耐受的作用。
Dendritic cells are characterized by their ability to efficiently present antigen , and are uniquely equipped to stimulate naive t cell responses . immature dendritic cells acquire antigens from throughout the peripheral body , then migrate to t - lymphocyte - dependent areas of lymph nodes . thus , dendritic cells act as bridges , operating at the interface of innate and acquired immunity 作為機體免疫系統(tǒng)中功能最強的專職性抗原提呈細胞( antigen - presentingcells , apc ) ,樹突狀細胞( dendriticcells , dc )能高效地攝取、加工處理和提呈抗原,具有較強的遷移能力,并能顯著地激活初始型t細胞以啟動t細胞免疫應答反應,此外, dc與b細胞以及nk細胞等也存在著相互作用,可見, dc在連接天然免疫和獲得性免疫之間起著非常重要的作用。
Porcine il - 12 ( pil - 12 ) , also termed as natural killer cell stimulatory factor ( nksf ) and cytotoxic lymphocyte maturation factor ( clmf ) , can induce some cytokines , particularly ifn - , from t and nk cells , as well as enhance the cytotoxic activity of these cells . its most critical role may be to initiate the development of cell - mediated immunity by promoting the differentiation of th1 cells from naive t cells 白細胞介素- 12 ( il - 12 )又名nk細胞刺激因子( nksf )或細胞毒淋巴細胞成熟因子( clmf ) ,能誘導t細胞和nk細胞產(chǎn)生ifn - ,并增強其細胞毒活性,它的關鍵作用是能誘導th0細胞分化為th1細胞以激發(fā)細胞免疫進程。
百科解釋
A naive T cell or Th0 cell is a T cell that has differentiated in bone marrow, and successfully undergone the positive and negative processes of central selection in the thymus. A naive T cell is considered mature and unlike activated T cells or memory T cells it has not encountered its cognate antigen within the periphery.